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The study was funded by a grant of the European Commission (INNOTUB II - EFA115/01, Interreg POCTEFA 2021-2027 program, co funded by the ERDF) , the Department of Agriculture, Livestock, Fisheries and Food (DARPA) of the Government of Catalonia, and the Spanish Ministry of Agriculture, Fisheries and Food (MAPA) . IRTA is supported by Centres de Recerca de Catalunya (CERCA) Programme/Generalitat de Catalunya ( www.cerca.cat) .

Analysis of institutional authors

De Val, Bernat PerezCorresponding AuthorVidal, EnricAuthor

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March 14, 2025
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Zoonotic tuberculosis in Catalonia, Spain: Phylogenetic insights into Mycobacterium bovis and M. caprae transmission at the human-livestock interface

Publicated to:One Health. 20 100993- - 2025-06-01 20(), DOI: 10.1016/j.onehlt.2025.100993

Authors: de Val, Bernat Perez; Vidal, Enric; Stuber, Tod; Saez, Jose Luis; Tortola, Maria Teresa

Affiliations

Anim & Plant Hlth Inspect Serv, Natl Vet Serv Labs, USDA, Vet Serv, Ames, IA USA - Author
Campus UAB, Unitat Mixta Invest IRTA UAB Sanitat Anim, CReSA, Bellaterra, Catalonia, Spain - Author
Campus Univ Autonoma Barcelona UAB, Ctr Recerca Sanitat Anim CReSA, IRTA, Anim Hlth, Bellaterra 08193, Catalonia, Spain - Author
Inst Salud Carlos III, CIBER Infect Dis CIBERINFEC, Madrid, Spain - Author
Minist Agr Pesca & Alimentac, Subdirecc Gen San Higiene Anim & Trazabil, Direcc Gen San Prod Agr, Madrid, Spain - Author
Vall dHebron Univ Hosp HUVH, Vall dHebron Res Inst VHIR, Microbiol Serv, WHO Supranatl TB Reference Lab, Barcelona, Catalonia, Spain - Author
WOAH Collaborating Ctr Res & Control Emerging & Re, Bellaterra, Catalonia, Spain - Author
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Abstract

This genomic epidemiology study analyzed Mycobacterium bovis and M. caprae isolates from animals and humans in Catalonia, Spain, between 2005 and 2023. Of 42 human tuberculosis (TB) cases, five were phylogenetically linked to livestock outbreaks, suggesting zoonotic transmission. The findings specifically indicate goats as a primary source of M. caprae transmission to humans. The study also revealed unexpected genetic diversity of mycobacteria within the same outbreak or even within the same patient, highlighting the complexity of tuberculosis transmission dynamics. The results underscore the value of genomic surveillance in understanding zoonotic TB transmission at the human-livestock interface and its role in informing effective control strategies.

Keywords

CattleClonal complexGenomic epidemiologyGoatInfectioMycobacterium bovisMycobacterium capraeSmall ruminanWhole genome sequencingZoonotic tuberculosis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal One Health due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 19/137, thus managing to position itself as a Q1 (Primer Cuartil), in the category Infectious Diseases.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-10:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 12.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 10 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.45.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.12327/3682

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (PEREZ DE VAL, BERNAT) .

the author responsible for correspondence tasks has been PEREZ DE VAL, BERNAT.