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Grant support

The present study was supported by grant PI17/01465 (AO) from the Instituto de Salud Carlos III, co-financed by the Fondo Europeo de Desarrollo Regional (FEDER) Una manera de hacer Europa and funding from the European Union's Horizon 2020 research and innovation program under grant European AIDS Vaccine Initiative 2020 (EAVI2020) #GA681137 (CB), La Caixa Foundation under the project code HR17-00199 and by a grant from the National Institute of Allergy and Infectious Diseases under award number PO1-AI131568. CB is a Senior ICREA research professor.

Analysis of institutional authors

Tarres-Freixas, FAuthor
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Article

T-Follicular-Like CD8(+) T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG

Publicated to:Frontiers In Immunology. 13 928039- - 2022-06-15 13(), DOI: 10.3389/fimmu.2022.928039

Authors: Romero-Martin, L; Tarres-Freixas, F; Pedreno-Lopez, N; de la Concepcion, MLR; Cunyat, F; Hartigan-O'Connor, D; Carrillo, J; Mothe, B; Blanco, J; Ruiz-Riol, M; Brander, C; Olvera, A

Affiliations

AELIX Therapeut, Barcelona, Spain - Author
Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain - Author
Hosp Germans Trias i Pujol, IrsiCaixa AIDS Res Inst, Inst Hlth Sci Res Germans Trias i Pujol IGTP, Badalona, Spain - Author
Hosp Univ Germans Trias i Pujol, Infect Dis Dept, Fdn Lluita Sida, Badalona, Spain - Author
Inst salud Carlos III, Ctr Invest Biomed Red, CIBERINFEC, Madrid, Spain - Author
Univ Autonoma Barcelona, Dept Biol Cellular Fisiol & Immunol, Cerdanyola Del Valles, Spain - Author
Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA USA - Author
Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA USA - Author
Univ Calif San Francisco, Div Expt Med, San Francisco, CA USA - Author
Univ Vic, Cent Univ Catalonia, Vic, Spain - Author
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Abstract

T cell responses are considered critical for the in vivo control of HIV, but the contribution of different T cell subsets to this control remains unclear. Using a boosted flow cytometric approach that is able to differentiate CD4(+) and CD8(+) T cell Th1/Tc1, Th2/Tc2, Th17/Tc17, Treg and Tfh/Tfc-like HIV-specific T cell populations, we identified CD8(+) Tfc responses that were related to HIV plasma viral loads and associated with rate of antibody isotype class switching to IgG. This favorable balance towards IgG responses positively correlated with increased virus neutralization, higher avidity of neutralizing antibodies and more potent antibody-dependent cell cytotoxicity (ADCC) in PBMCs from HIV controllers compared to non-controllers. Our results identified the CD8(+) Tfc-like T-cell response as a component of effective virus control which could possibly be exploited therapeutically.

Keywords
hivhuman immunodeficiency virus (hiv) controlhumoral immune responset-follicular cytotoxic (tfc) cellsAssayCd4GagHeterogeneityHivHuman immunodeficiency virus (hiv) controlHumoral immune responseIndividualsNeutralizationPhenotypeT-follicular cytotoxic (tfc) cellsTfh cellsViral control

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers In Immunology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 35/161, thus managing to position itself as a Q1 (Primer Cuartil), in the category Immunology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-04-29:

  • WoS: 1
  • Scopus: 2
  • OpenCitations: 1
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-04-29:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 22.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 22 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.1.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.