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Analysis of institutional authors

Carmona-Vicente, NAuthor

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June 6, 2023
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Characterisation of a household norovirus outbreak occurred in Valencia (Spain)

Publicated to: Bmc Infectious Diseases. 16 124- - 2016-03-12 16(), DOI: 10.1186/s12879-016-1455-9

Authors:

Carmona-Vicente, Noelia; Fernandez-Jimenez, Manuel; Vila-Vicent, Susana; Rodriguez-Diaz, Jesus; Buesa, Javier
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Affiliations

Univ Valencia, Dept Microbiol, Sch Med, Avda Blasco Ibanez 17, Valencia 46010, Spain - Author

Abstract

Background: Human noroviruses (NoVs) are the main cause of non-bacterial gastroenteritis worldwide. Several studies have linked human susceptibility to NoVs with the expression of histo-blood group antigens (HBGAs). In January 2012, a NoV gastroenteritis outbreak affected a household in Valencia, Spain, and the personal susceptibility to NoV was investigated. Methods: To reach this aim 8 members of the affected household were recruited for this study and their secretor status, ABO and Lewis antigens were determined. NoV-specific saliva IgA and serum IgG antibody titers were analyzed. Their capacity to block viral binding to saliva receptors was analyzed, using virus-like particles (VLPs) of the NoV GII. 4 genotype, 2006b variant, and saliva from a secretor O blood type donor. Results: The most relevant finding was that an asymptomatic non-secretor individual shed NoVs in his stools. Interestingly, anti-NoV IgA antibody titers in saliva from secretor and non-secretor individuals showed no differences. On the contrary, high titers of NoV-specific IgG antibody were found in both convalescent sera and in sera collected 1 year post-infection, but only from secretor individuals. NoV GII.4-2006b VLP binding to receptors present in the saliva was efficiently blocked only by sera from secretor positive individuals. Conclusions: Despite the small number of individuals involved in this outbreak, this study reinforces the idea that susceptibility to human NoV is both dependent on the HBGA profile of the individuals as well as on the viral genotype and variant. We also show that the immunity to NoV lasts for at least 1 year after infection, demonstrating that symptomatic infections strongly stimulate immune responses.
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Keywords

binding assayfut2histo-blood group antigensigaiggnorovirussecretorsusceptibilityBinding assayBlood group antigensEnteric bacteriaEvolutionFut2GastroenteritisHisto-blood group antigensIgaIggNonsense mutationNorovirusNorwalk virus-infectionPhenotypeResistanceSecretorSusceptibilityVirus-like particles

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal BMC Infectious Diseases due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2016, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Infectious Diseases.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-11:

  • WoS: 9
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-11:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 30 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (CARMONA VICENTE, NOELIA) .

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Awards linked to the item

This work was supported by the Ministry of Economy and Competitiveness (SAF2012-38368). Noelia Carmona-Vicente was recipient of a V Segles fellowship from the University of Valencia and Jesus Rodriguez-Diaz was recipient of a Ramon y Cajal contract from the Ministry of Economy and Competitiveness (RYC-2013-12442). Special thanks to Lidia Camilleri-Chorda, as nurse, for her work and support during the blood sample collection.
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